External transportability of bacterial- and viral-associated host-response modules across public transcriptomic cohorts
PLOS ONE
Authors
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Dr. Reuben Maghembe on this important contribution to infectious disease research
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computational biology
Abstract
has been published in PLOS ONE
The study investigates whether biologically defined whole-blood host-response modules associated with bacterial and viral infections retain their expected patterns when applied to independent transcriptomic cohorts.
Notably, all five predefined host-response modules retained their expected directions across two external cohorts. Four modules; one associated with bacterial mitochondrial respiration and oxidative phosphorylation, and three associated with antiviral, interferon, viral-restriction, cytokine and innate immune responses showed strong and reproducible statistical support across both cohorts.
The findings contribute to the growing field of host-response biology and transcriptomics, while highlighting the importance of assessing biological transportability and robustness across datasets, platforms and analytical approaches.
Summary as published by the college when announcing this work. See the journal article for the full abstract.
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